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Mechanosensitive channel activation by diffusio-osmotic force.

Abstract:

For ion channel gating, the appearance of two distinct conformational states and the discrete transitions between them are essential, and therefore of crucial importance to all living organisms. We show that the physical interplay between two structural elements that are commonly present in bacterial mechanosensitive channels--namely, a charged vestibule and a hydrophobic constriction--creates two distinct conformational states, open and closed, as well as the gating between them. We solve th...

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Authors


Bonthuis, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Publisher:
American Physical Society
Journal:
Physical review letters
Volume:
113
Issue:
14
Pages:
148101
Publication date:
2014-10-05
DOI:
EISSN:
1079-7114
ISSN:
0031-9007
URN:
uuid:ba3cb178-21a6-49ae-a724-e26d318cfff6
Source identifiers:
488999
Local pid:
pubs:488999
Language:
English

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