Journal article

Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis

Abstract:: Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.

Objective To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.

Data Sources Trials were identified through systematic searches of electronic databases betwee...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Shankar-Hari, M., Vale, C. L., Godolphin, P. J., Haynes, R., Horby, P. W., Landray, M. J., & Staplin, N. (2021). Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis. Journal of the American Medical Association, 326(6), 499–518.

MLA Style

Shankar-Hari, M., et al. “Association between Administration of IL-6 Antagonists and Mortality among Patients Hospitalized for COVID-19: a Meta-Analysis.” Journal of the American Medical Association, vol. 326, no. 6, American Medical Association, 2021, pp. 499–518.

Chicago Style

Shankar-Hari, M, CL Vale, PJ Godolphin, R Haynes, PW Horby, MJ Landray, and N Staplin. 2021. “Association between Administration of IL-6 Antagonists and Mortality among Patients Hospitalized for COVID-19: a Meta-Analysis.” Journal of the American Medical Association 326 (6): 499–518.
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Publisher copy:: 10.1001/jama.2021.11330

Authors

+ Shankar-Hari, M More by this author

Role:: Author

+ Vale, CL More by this author

Role:: Author

+ Godolphin, PJ More by this author

Role:: Author

+ Haynes, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author
ORCID:: 0000-0002-1179-0023

+ Horby, PW More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Tropical Medicine
Role:: Author

More authors...

Contributors

+ WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group

Role:: Contributor

Publisher:: American Medical Association
Journal:: Journal of the American Medical Association More from this journal
Volume:: 326
Issue:: 6
Pages:: 499-518
Publication date:: 2021-07-06
Acceptance date:: 2021-06-24
DOI:: 10.1001/jama.2021.11330
EISSN:: 1538-3598
ISSN:: 0098-7484

Language:: English
Keywords:: FFR
Pubs id:: 1185536
Local pid:: pubs:1185536
Deposit date:: 2021-07-12

Terms of use

Copyright holder:: American Medical Association
Copyright date:: 2021
Rights statement:: © 2021 American Medical Association. All rights reserved.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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