Journal article
Hydrodifluoromethylation of alkenes with difluoroacetic acid
- Abstract:
- A facile method for the regioselective hydrodifluoromethylation of alkenes is reported using difluoroacetic acid and phenyliodine(III) diacetate in tetrahydrofuran under visible‐light activation. This metal‐free approach stands out as it uses inexpensive reagents, does not require a photocatalyst, and displays broad functional group tolerance. The procedure is also operationally simple and scalable, and provides access in one step to high‐value building blocks for application in medicinal chemistry.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 589.5KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 6.3MB, Terms of use)
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- Publisher copy:
- 10.1002/anie.201903801
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 58
- Issue:
- 26
- Pages:
- 8829-8833
- Publication date:
- 2019-05-24
- Acceptance date:
- 2019-04-16
- DOI:
- ISSN:
-
1433-7851
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:994898
- UUID:
-
uuid:ba1421fa-3d9b-4c2f-923a-aad806535c32
- Local pid:
-
pubs:994898
- Source identifiers:
-
994898
- Deposit date:
-
2019-04-29
- ARK identifier:
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH & Co KGaA, Weinheim
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at https://doi.org/10.1002/anie.201903801
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