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Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex.

Abstract:

Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90KD Ti heterodimer and the monomorphic 20/25KD T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and fully expressed during late thymic ontogeny, thus p...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Immunological reviews
Volume:
81
Issue:
1
Pages:
95-129
Publication date:
1984-10-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:ba0c9780-3ddb-460e-b7a6-9e83cd5ab06c
Source identifiers:
16182
Local pid:
pubs:16182

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