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Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

Abstract:

Glioblastoma multiforme (GBM) remains a cancer with a poor prognosis and few effective therapeutic options. Successful medical management of GBM is limited by the restricted access of drugs to the central nervous system (CNS) caused by the blood brain barrier (BBB). We previously showed that a subset of GBM are arginine auxotrophic because of transcriptional silencing of ASS1 and/or ASL and are sensitive to pegylated arginine deiminase (ADI-PEG20). However, it is unknown whether depletion of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41419-018-1195-4

Authors


Przystal, JM More by this author
Khozoie, C More by this author
Renziehausen, A More by this author
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Brain Tumour Research Campaign More from this funder
Brain Tumour Research More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
9
Issue:
12
Pages:
1192
Publication date:
2018-12-13
Acceptance date:
2018-10-29
DOI:
EISSN:
2041-4889
Pubs id:
pubs:952891
URN:
uri:b9ffe66a-dbec-4317-8100-bcdbef1b70e3
UUID:
uuid:b9ffe66a-dbec-4317-8100-bcdbef1b70e3
Local pid:
pubs:952891
Language:
English
Keywords:
Subjects:

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