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Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts.

Abstract:

In the pathogenesis of dilated cardiomyopathy, cytoskeletal proteins play an important role. In this study, we analyzed titin expression in left ventricles of 19 control human donors and 9 severely diseased (nonischemic) dilated cardiomyopathy (DCM) transplant-patients, using gel-electrophoresis, immunoblotting, and quantitative RT-PCR. Both human-heart groups coexpressed smaller (approximately 3 MDa) N2B-isoform and longer (3.20 to 3.35 MDa) N2BA-isoforms, but the average N2BA:N2B-protein ra...

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Authors


Makarenko, I More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, REF-Physics
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Journal:
Circulation research
Volume:
95
Issue:
7
Pages:
708-716
Publication date:
2004-10-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:b9f0509b-29d3-4ccc-9d75-0bd8a5e74a14
Source identifiers:
160919
Local pid:
pubs:160919

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