Journal article
Mediodorsal thalamus is critical for updating during extradimensional shifts but not reversals in the attentional set-shifting task
- Abstract:
- Cognitive flexibility, attributed to frontal cortex, is vital for navigating the complexities of everyday life. The mediodorsal thalamus (MD), interconnected to frontal cortex, may influence cognitive flexibility. Here, male rats performed an attentional set-shifting task measuring intradimensional (ID) and extradimensional (ED) shifts in sensory discriminations. MD lesion rats needed more trials to learn the rewarded sensory dimension. However, once the choice response strategy was established, learning further two-choice discriminations in the same sensory dimension, and reversals of the reward contingencies in the same dimension, were unimpaired. Critically though, MD lesion rats were impaired during the ED shift, when they must rapidly update the optimal choice response strategy. Behavioral analyses showed MD lesion rats had significantly reduced correct within-trial second choice responses. This evidence shows that transfer of information via the MD is critical when rapid within-trial updates in established choice response strategies are required after a rule change.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, 1.6MB, Terms of use)
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- Publisher copy:
- 10.1523/eneuro.0162-21.2022
Authors
- Publisher:
- Society for Neuroscience
- Journal:
- eNeuro More from this journal
- Volume:
- 9
- Issue:
- 2
- Publication date:
- 2022-02-01
- Acceptance date:
- 2022-01-11
- DOI:
- EISSN:
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2373-2822
- Language:
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English
- Keywords:
- Pubs id:
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1237311
- Local pid:
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pubs:1237311
- Deposit date:
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2022-02-02
Terms of use
- Copyright holder:
- Ouhaz et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 Ouhaz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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