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In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

Abstract:

Rapid binding of peptides to MHC class II molecules is normally limited to a deep endosomal compartment where the coordinate action of low pH and HLA-DM displaces the invariant chain remnant CLIP or other peptides from the binding site. Exogenously added peptides are subject to proteolytic degradation for extended periods of time before they reach the relevant endosomal compartment, which limits the efficacy of peptide-based vaccines and therapeutics. In this study, we describe a family of sm...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0803464

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
182
Issue:
10
Pages:
6342-6352
Publication date:
2009-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:b9cde42c-4ca1-4c57-a631-7c7565bc3b01
Source identifiers:
314774
Local pid:
pubs:314774

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