High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis

Journal article

Background: Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis (OA). We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA (WKROA). Methods: We performed a nested case-control study of incident WKROA in MOST, a cohort of 3,026 men and women aged 50-79 years with, or at high risk of, knee OA. Incident cases were knees without either tibiofemoral (TF) or patellofemoral (PF...

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Authors: Chaganti, R; Tolstykh, I; Javaid, M; Neogi, T; Torner, J

• Journal: Osteoarthritis and Cartilage
• Volume: 22
• Issue: 2
• Pages: 190-196
• Publication date: 2014-02-01
• DOI: 10.1016/j.joca.2013.11.008
• EISSN: 1522-9653
• ISSN: 1063-4584
• Language: English
• Keywords: Knee osteoarthritis; Antioxidants; Vitamin C; Vitamin E