Exact calculations of survival probability for diffusion on growing lines, disks, and spheres: The role of dimension

Journal article

Unlike standard applications of transport theory, the transport of molecules and cells during embryonic development often takes place within growing multidimensional tissues. In this work, we consider a model of diffusion on uniformly growing lines, disks, and spheres. An exact solution of the partial differential equation governing the diffusion of a population of individuals on the growing domain is derived. Using this solution, we study the survival probability, S(t). For the standard non-growing case with an absorbing boundary, we observe that S(t) decays to zero in the long time limit. In contrast, when the domain grows linearly or exponentially with time, we show that S(t) decays to a constant, positive value, indicating that a proportion of the diffusing substance remains on the growing domain indefinitely. Comparing S(t) for diffusion on lines, disks, and spheres indicates that there are minimal differences in S(t) in the limit of zero growth and minimal differences in S(t) in the limit of fast growth. In contrast, for intermediate growth rates, we observe modest differences in S(t) between different geometries. These differences can be quantified by evaluating the exact expressions derived and presented here.

Authors: Simpson, MJ; Baker, RE

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Institute of Physics Publishing
• Journal: Journal of Chemical Physics
• Volume: 143
• Issue: 9
• Article number: 094109
• Publication date: 2015-09-04
• Acceptance date: 2015-08-21
• DOI: 10.1063/1.4929993
• EISSN: 1089-7690
• ISSN: 0021-9606
• Language: English