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Journal article

Loss of NRF2 impairs gastric nitrergic stimulation and function.

Abstract:

Emerging research suggests that antioxidant gene expression has the potential to suppress the development of gastroparesis. However, direct genetic evidence that definitively supports this concept is lacking. We used mice carrying a targeted disruption of Nfe2l2, the gene that encodes the transcription factor NRF2 and directs antioxidant Phase II gene expression, as well as mice with a targeted disruption of Gclm, the modifier subunit for glutamate-cysteine ligase, to test the hypothesis that...

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Publication status:
Published

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Authors


Mukhopadhyay, S More by this author
Sekhar, KR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Farrugia, G More by this author
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Journal:
Free radical biology and medicine
Volume:
51
Issue:
3
Pages:
619-625
Publication date:
2011-08-05
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
URN:
uuid:b96de8f8-3374-4b8b-83e2-40bc7bb739e2
Source identifiers:
142184
Local pid:
pubs:142184

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