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A highly acid labile silicon linker for solid phase synthesis

Abstract:
A novel arylsilane based linker has been prepared for the solid phase synthesis of small molecule combinatorial libraries. Efficient cleavage is achieved using TFA via anchimerically assisted protiodesilylation to yield aromatic products possessing no residual linker functionality.
Publication status:
Published

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Publisher copy:
10.1016/S0040-4039(97)10650-5

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
39
Issue:
8
Pages:
897-900
Publication date:
1998-02-19
DOI:
ISSN:
0040-4039


Language:
English
Pubs id:
pubs:110639
UUID:
uuid:b91b556d-3a54-48cf-aeef-338ae52050a8
Local pid:
pubs:110639
Source identifiers:
110639
Deposit date:
2012-12-19

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