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Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Abstract:

Sensitive and reliable methods are required for the assessment of oxidative DNA damage, which can result from reactive oxygen species that are generated endogenously from cellular metabolism and inflammatory responses, or by exposure to exogenous agents. The development of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) selected reaction monitoring (SRM) method is described, that utilises online column-switching valve technology for the simultaneous determination of two DNA adduct...

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Publication status:
Published

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Publisher copy:
10.1002/rcm.3866

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Journal:
Rapid communications in mass spectrometry : RCM
Volume:
23
Issue:
1
Pages:
151-160
Publication date:
2009-01-05
DOI:
EISSN:
1097-0231
ISSN:
0951-4198
URN:
uuid:b8f09317-5b8c-463c-bc7d-6204481f28f5
Source identifiers:
132103
Local pid:
pubs:132103

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