Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum.

Journal article

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

Authors: Cavanagh, DR; Dobaño, C; Elhassan, I; Marsh, K; Elhassan, A

• Publication status: Published
• Journal: Infection and immunity
• Volume: 69
• Issue: 2
• Pages: 1207-1211
• Publication date: 2001-02-01
• DOI: 10.1128/iai.69.2.1207-1211.2001
• EISSN: 1098-5522
• ISSN: 0019-9567
• Language: English
• Keywords: Humans; Animals; Middle Aged; Adult; Child; Plasmodium falciparum; Infant; Adolescent; Antibodies, Protozoan; Peptide Fragments; Immunoglobulin G; Child, Preschool; Aged; Merozoite Surface Protein 1