- Abstract:
-
Protein folding can be described in terms of the development of specific contacts between residues as a highly disordered polypeptide chain converts into the native state. Here we describe an NMR based strategy designed to detect such contacts by observation of nuclear Overhauser effects (NOEs). Experiments with alpha-lactalbumin reveal the existence of extensive NOEs between aromatic and aliphatic protons in the archetypal molten globule formed by this protein at low pH. Analysis of their ti...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.94.14.7182
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 94
- Issue:
- 14
- Pages:
- 7182-7185
- Publication date:
- 1997-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:b8df7864-a4a9-46c3-abac-e160ee713f7e
- Source identifiers:
-
30993
- Local pid:
- pubs:30993
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Detection of residue contacts in a protein folding intermediate.
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