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Detection of residue contacts in a protein folding intermediate.

Abstract:

Protein folding can be described in terms of the development of specific contacts between residues as a highly disordered polypeptide chain converts into the native state. Here we describe an NMR based strategy designed to detect such contacts by observation of nuclear Overhauser effects (NOEs). Experiments with alpha-lactalbumin reveal the existence of extensive NOEs between aromatic and aliphatic protons in the archetypal molten globule formed by this protein at low pH. Analysis of their ti...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.14.7182

Authors


Balbach, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Atomic and Laser Physics
van Nuland, NA More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
14
Pages:
7182-7185
Publication date:
1997-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b8df7864-a4a9-46c3-abac-e160ee713f7e
Source identifiers:
30993
Local pid:
pubs:30993
Language:
English
Keywords:

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