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Functional parameters derived from magnetic resonance imaging reflect vascular 1 morphology in preclinical tumors and in human liver metastases

Abstract:

Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and mo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1158/1078-0432.CCR-18-0033

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Kretzschmar, W More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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More from this funder
Grant:
C5255/A12678
C2522/A10339
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Grant:
C5255/A12678
C2522/A10339
C5255/A15935
Engineering and Physical Sciences Research Council More from this funder
KTH Royal Institute of Technology More from this funder
National Institute for Health Research More from this funder
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
24
Issue:
19
Pages:
4694–4704
Publication date:
2018-06-29
Acceptance date:
2018-06-25
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pubs id:
pubs:856975
URN:
uri:b8d4fb4e-77bc-4be7-b6f1-981050303798
UUID:
uuid:b8d4fb4e-77bc-4be7-b6f1-981050303798
Local pid:
pubs:856975

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