Viral fusion: how Flu induces dimples on liposomes.
Membrane fusion--a basic cellular process enabling crucial cellular functions such as membrane trafficking--is mechanistically only partially understood. Most of the existing knowledge has come from studying host-cell entry of viruses with lipid bilayer envelopes, which proceeds through fusion of viral and host-cell membranes.Crystal structures for a number of viral fusion proteins facilitating this process have contributed substantially to our understanding. One of the next challenges is to ...Expand abstract
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