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Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).

Abstract:

The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. We identified genetic variation in the basal promoter region of CNT2 and characterized the function of the variants. We screened DNA from an ethnically diverse population and identified five basal promoter variants in CNT2. Three major haplotypes in the CNT2 basal promoter region were identified and were f...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.108.147207

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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
328
Issue:
3
Pages:
699-707
Publication date:
2009-03-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:b8b61b40-2bb1-415e-8079-de19b0471a30
Source identifiers:
68180
Local pid:
pubs:68180

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