The oxazolomycins: a structurally novel class of bioactive compounds.

Journal article

Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycin...

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Authors: Moloney, M; Trippier, P; Yaqoob, M; Wang, Z

• Journal: Current drug discovery technologies
• Volume: 1
• Issue: 3
• Pages: 181-199
• Publication date: 2004-10-01
• DOI: 10.2174/1570163043334974
• EISSN: 1875-6220
• ISSN: 1570-1638
• Language: English
• Keywords: Oxazoles; Magnetic Resonance Spectroscopy; Anti-Bacterial Agents; Antiviral Agents; Spiro Compounds; Antibiotics, Antineoplastic; Models, Molecular