Journal article
Domain-specific cognitive impairments, mood and quality of life 6 months after stroke
- Abstract:
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Purpose: To identify which acute and 6-month domain-specific cognitive impairments impact mood, participation, and stroke-related quality of life 6 months post-stroke.
Materials and methods: A prospective cohort of 430 stroke survivors completed the Oxford Cognitive Screen (OCS) acutely and 6 months post-stroke. Participants completed the Stroke Impact Scale (SIS) and Hospital Depression and Anxiety Scale (HADS) at 6 months. Multivariable regression analyses assessed whether severity of, and domain-specific, cognitive impairment acutely and at 6 months was associated with composite 6-month SIS scores, each SIS subscale, and HADS scores.
Results: Increased severity of acute and 6-month cognitive impairment was associated with lower 6-month SIS composite scores independent of age, sex, education years, and stroke severity (both p < 0.001). Domain-specific impairments in memory (p < 0.001) and attention (p = 0.002) acutely, and language (p < 0.001), memory (p = 0.001) and number processing (p = 0.006) at 6 months showed the strongest associations with worse SIS composite scores. Severity of acute and 6-month cognitive impairment was associated with poorer functioning in each SIS subscale, and greater levels of depression (acute p = 0.021, 6-months p < 0.001), but not anxiety (p = 0.174, p = 0.129).
Conclusions: Both acute and 6-month domain-specific cognitive impairments, particularly in memory, were found to negatively impact overall functional and mood outcomes 6 months post-stroke.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.4MB, Terms of use)
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- Publisher copy:
- 10.1080/09638288.2024.2340121
Authors
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- NIHR204290
- Publisher:
- Taylor & Francis
- Journal:
- Disability and Rehabilitation More from this journal
- Volume:
- 47
- Issue:
- 2
- Pages:
- 435-444
- Publication date:
- 2024-04-16
- Acceptance date:
- 2024-04-03
- DOI:
- EISSN:
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1464-5165
- ISSN:
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0963-8288
- Pmid:
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38623852
- Language:
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English
- Keywords:
- Pubs id:
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1991083
- Local pid:
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pubs:1991083
- Deposit date:
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2025-04-23
- ARK identifier:
Terms of use
- Copyright holder:
- Milosevich et al.
- Copyright date:
- 2024
- Rights statement:
- © 2024 the author(s). Published by informa UK limited, trading as taylor & Francis Group. This an open access article distributed under the terms of the Creative Commons attribution license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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