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Should first-line empiric treatment strategies cover coagulase-negative Staphylococcal infections in severely malnourished or HIV-infected children in Kenya

Abstract:

BACKGROUND:
Bloodstream infection is a common cause of morbidity in children aged <5 years in developing countries. In studies reporting bacteremia in Africa, coagulase-negative Staphylococci (CoNS) are commonly isolated. However, it is currently unclear whether children who are highly susceptible to infection because of severe acute malnutrition (SAM) or HIV should be treated with antimicrobials specifically to cover CoNS. We aimed to determine the clinical significance of CoNS amon...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0182354

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSd, Obstetrics & Gynaecology
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Grant:
093804, 092088, 083579, 077092
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
8
Pages:
e0182354
Publication date:
2017-08-07
Acceptance date:
2017-07-17
DOI:
ISSN:
1932-6203
Pubs id:
pubs:713446
URN:
uri:b88629d6-a6bc-4445-a6ee-6eb692a09e6a
UUID:
uuid:b88629d6-a6bc-4445-a6ee-6eb692a09e6a
Local pid:
pubs:713446

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