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Journal article

Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.

Abstract:

OBJECTIVE: To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7. METHODS: Knee OA patients from 2 UK cohorts (1,411 from the Genetics of Osteoarthritis and Lifestyle study and 267 from the Hertfordshire Cohort Study; 74% with symptomatic OA) with Western Ontario and McMaster Universities OA Index (WOMAC) pain scores were genotyped for rs674...

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Publication status:
Published

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Publisher copy:
10.1002/acr.20375

Authors


Valdes, AM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Vaughn, FL More by this author
Doherty, SA More by this author
Leaverton, PE More by this author
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Journal:
Arthritis care and research
Volume:
63
Issue:
3
Pages:
440-444
Publication date:
2011-03-05
DOI:
EISSN:
2151-4658
ISSN:
2151-464X
URN:
uuid:b881a5df-36d5-420f-8cca-d9ea9cf02c7d
Source identifiers:
107419
Local pid:
pubs:107419

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