Entorhinal cortex contributes to object-in-place scene memory.

Journal article

Four rhesus monkeys (Macaca mulatta) were trained preoperatively in a test of object-in-place scene memory. They were presented daily with lists of unique computer-generated scenes each containing a spatial array of multiple individual objects. Within each scene, objects to be discriminated appeared in the foreground, each occupying a unique location, and monkeys were required to correctly discriminate the rewarded object to receive a food reward. Once this preoperative criterion was attained, the monkeys received bilateral entorhinal cortex ablation performed as either one or two surgical operations with a period of testing following each. Postoperatively, they were significantly impaired in learning new object-in-place scene problems. These results show that the entorhinal cortex, like anatomically related structures including the perirhinal cortex and the fornix, contributes to object-in-place scene learning.

Authors: Charles, D; Browning, P; Gaffan, D

• Publication status: Published
• Journal: European journal of neuroscience
• Volume: 20
• Issue: 11
• Pages: 3157-3164
• Publication date: 2004-12-01
• DOI: 10.1111/j.1460-9568.2004.03777.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Behavior, Animal; Reward; Catheter Ablation; Pattern Recognition, Visual; Brain Mapping; Photic Stimulation; Conditioning, Operant; Functional Laterality; Male; Animals; Macaca mulatta; Fornix, Brain; Memory; Discrimination Learning; Entorhinal Cortex