Journal article : Review
Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries
- Abstract:
- The advent of single-cell resolution sequencing and spatial transcriptomics has enabled the delivery of cellular and molecular atlases of tissues and organs, providing new insights into tissue health and disease. However, if the full potential of these technologies is to be equitably realised, ancestrally inclusivity is paramount. Such a goal requires greater inclusion of both researchers and donors in low- and middle-income countries (LMICs). In this perspective, we describe the current landscape of ancestral inclusivity in genomic and single-cell transcriptomic studies. We discuss the collaborative efforts needed to scale the barriers to establishing, expanding, and adopting single-cell sequencing research in LMICs and to enable globally impactful outcomes of these technologies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1038/s41431-024-01564-4
Authors
- Publisher:
- Springer Nature
- Journal:
- European Journal of Human Genetics More from this journal
- Volume:
- 32
- Issue:
- 10
- Pages:
- 1206-1213
- Publication date:
- 2024-04-02
- Acceptance date:
- 2024-02-06
- DOI:
- EISSN:
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1476-5438
- ISSN:
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1018-4813
- Pmid:
-
38565638
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1987716
- Local pid:
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pubs:1987716
- Deposit date:
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2024-06-04
Terms of use
- Copyright holder:
- Boakye Serebour et al.
- Copyright date:
- 2024
- Rights statement:
- Copyright © 2024, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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