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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.

Abstract:

Pioneering work in the 1960s defined prolyl and lysyl hydroxylations as physiologically important oxygenase-catalyzed modifications in collagen biosynthesis; subsequent studies demonstrated that extracellular epidermal growth factor-like domains were hydroxylated at aspartyl and asparaginyl residues. More recent work on the hypoxia-sensing mechanism in animals has shown that prolyl and asparaginyl hydroxylation of the hypoxia-inducible transcription factor play central roles in sensing hypoxi...

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Publication status:
Published

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Publisher copy:
10.1016/j.tibs.2010.07.002

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Trends in biochemical sciences
Volume:
36
Issue:
1
Pages:
7-18
Publication date:
2011-01-05
DOI:
ISSN:
0968-0004
URN:
uuid:b8634f65-a064-469f-8ceb-6c19bcf30133
Source identifiers:
67479
Local pid:
pubs:67479

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