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The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.

Abstract:

BACKGROUND: The microsomal triglyceride transfer protein (MTP) transfers lipids into apolipoprotein B-containing lipoproteins for secretion from liver, intestine, and heart. The T-variant of a functional polymorphism in the MTP promoter, MTP-493G/T, has been associated with reduced low-density lipoprotein cholesterol concentrations. We hypothesize that this polymorphism impacts on coronary heart disease (CHD) risk. METHODS AND RESULTS: The effect of the polymorphism was therefore tested in t...

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Publication status:
Published

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Journal:
Circulation More from this journal
Volume:
109
Issue:
19
Pages:
2279-2284
Publication date:
2004-05-10
DOI:
EISSN:
1524-4539
ISSN:
0009-7322

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