The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.

Journal article

BACKGROUND: The microsomal triglyceride transfer protein (MTP) transfers lipids into apolipoprotein B-containing lipoproteins for secretion from liver, intestine, and heart. The T-variant of a functional polymorphism in the MTP promoter, MTP-493G/T, has been associated with reduced low-density lipoprotein cholesterol concentrations. We hypothesize that this polymorphism impacts on coronary heart disease (CHD) risk. METHODS AND RESULTS: The effect of the polymorphism was therefore tested in t...

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Authors: Ledmyr, H; McMahon, A; Ehrenborg, E; Nielsen, L; Neville, M

• Publication status: Published
• Journal: Circulation
• Volume: 109
• Issue: 19
• Pages: 2279-2284
• Publication date: 2004-05-10
• DOI: 10.1161/01.CIR.0000130070.96758.7b
• EISSN: 1524-4539
• ISSN: 0009-7322
• Language: English
• Keywords: Disease Susceptibility; Humans; Scotland; Genotype; Double-Blind Method; Middle Aged; Prospective Studies; Sweden; Pravastatin; WOSCOPS executive; Male; Myocardial Infarction; Myocardium; RNA, Messenger; Risk; Abetalipoproteinemia; Longitudinal Studies; Codon; Lipoproteins; Coronary Disease; Carrier Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Anticholesteremic Agents; Haplotypes; Polymorphism, Genetic; Biopsy; Cohort Studies; Lipid Metabolism; Case-Control Studies; Cholesterol, LDL; Promoter Regions, Genetic