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POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

Abstract:
Purpose: Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune response and clinical outcome in cancer, we investigated whether POLE-mutant ECs showed evidence of increased immunogenicity. Design: We examined immune infiltration and a... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
EU-FP7
Funding agency for:
Tomlinson, I
Grant:
258236
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Name:
Cancer Research UK
Funding agency for:
Tomlinson, I
Grant:
258236
More from this funder
Name:
Wellcome Trust
Funding agency for:
Church, D
Tomlinson, I
Freeman-Mills, L
Palles, C
Grant:
258236
More from this funder
Name:
Oxford Martin School
Funding agency for:
Church, D
Tomlinson, I
Freeman-Mills, L
Palles, C
Grant:
258236
More from this funder
Name:
National Institute for Health Research Biomedical Research Centre Programme
Funding agency for:
Klenerman, P
Publisher:
American Association for Cancer Research
Journal:
Clinical Cancer Research More from this journal
Volume:
21
Article number:
3347
Publication date:
2015-04-01
DOI:
EISSN:
1078-0432
ISSN:
1557-3265
Language:
English
Pubs id:
pubs:517177
UUID:
uuid:b84632c3-c44f-47f2-8717-f32c09da781d
Local pid:
pubs:517177
Source identifiers:
517177
Deposit date:
2015-04-28

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