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POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

Abstract:
Purpose: Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune response and clinical outcome in cancer, we investigated whether POLE-mutant ECs showed evidence of increased immunogenicity. Design: We examined immune infiltration and a... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.CCR-15-0057

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Church, D
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Funding agency for:
Church, D
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Funding agency for:
Tomlinson, I
Grant:
258236
More from this funder
Funding agency for:
Tomlinson, I
Grant:
258236
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
21
Article number:
3347
Publication date:
2015-04-01
DOI:
EISSN:
1078-0432
ISSN:
1557-3265
Source identifiers:
517177
Language:
English
Pubs id:
pubs:517177
UUID:
uuid:b84632c3-c44f-47f2-8717-f32c09da781d
Local pid:
pubs:517177
Deposit date:
2015-04-28

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