Journal article
POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
- Abstract:
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Purpose: Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune response and clinical outcome in cancer, we investigated whether POLE-mutant ECs showed evidence of increased immunogenicity. Design: We examined immune infiltration and a... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 139.6KB)
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- Publisher copy:
- 10.1158/1078-0432.CCR-15-0057
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Authors
Funding
+ National Institute for Health Research Biomedical Research Centre Programme
More from this funder
Funding agency for:
Klenerman, P
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Clinical Cancer Research Journal website
- Volume:
- 21
- Article number:
- 3347
- Publication date:
- 2015-04-01
- DOI:
- EISSN:
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1078-0432
- ISSN:
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1557-3265
- Source identifiers:
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517177
Item Description
- Language:
- English
- Pubs id:
-
pubs:517177
- UUID:
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uuid:b84632c3-c44f-47f2-8717-f32c09da781d
- Local pid:
- pubs:517177
- Deposit date:
- 2015-04-28
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from American Association for Cancer Research at: http://dx.doi.org/10.1158/1078-0432.CCR-15-0057
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