The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children.

Journal article

Children living in hyperendemic malarious regions have high immunoglobulin levels and an increased frequency of Burkitt's lymphoma. In a study of Gambian children which endeavours to explain these findings we showed that acute P. falciparum malaria caused spontaneous activation and growth of their B lymphocytes in vitro. A high proportion of these cells contained Epstein-Barr nuclear antigen (EBNA). In ancillary experiments aimed at explaining these findings. CD4 helper cells from adult donor...

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Authors: Whittle, H; Brown, J; Marsh, K; Blackman, M; Jobe, O

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 80
• Issue: 2
• Pages: 213-218
• Publication date: 1990-05-01
• DOI: 10.1111/j.1365-2249.1990.tb05236.x
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Child; Adolescent; Child, Preschool; Plasmodium falciparum; Cells, Cultured; T-Lymphocytes, Cytotoxic; Herpesvirus 4, Human; CD4-Positive T-Lymphocytes; Immunoglobulin G; B-Lymphocytes; Lymphocyte Activation; Humans; Immunoglobulin M; Cell Transformation, Viral; Malaria; Animals