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The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children.

Abstract:

Children living in hyperendemic malarious regions have high immunoglobulin levels and an increased frequency of Burkitt's lymphoma. In a study of Gambian children which endeavours to explain these findings we showed that acute P. falciparum malaria caused spontaneous activation and growth of their B lymphocytes in vitro. A high proportion of these cells contained Epstein-Barr nuclear antigen (EBNA). In ancillary experiments aimed at explaining these findings. CD4 helper cells from adult donor...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Clinical and experimental immunology More from this journal
Volume:
80
Issue:
2
Pages:
213-218
Publication date:
1990-05-01
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Language:
English
Keywords:
Pubs id:
pubs:184967
UUID:
uuid:b83a2d45-724d-4903-99b5-4c93b36000bd
Local pid:
pubs:184967
Source identifiers:
184967
Deposit date:
2012-12-19

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