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Journal article

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Abstract:

Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha cells but their activity is low and only ~1% of that in beta cells. Like beta cells, alpha cells respond to hyperglycaemia with K(ATP) channel closure, membrane depolarisation and ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-014-3279-8

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Diabetologia
Volume:
57
Issue:
9
Pages:
1749-1761
Publication date:
2014-09-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:b833024c-978b-4d23-bb07-23c93f5e1839
Source identifiers:
469379
Local pid:
pubs:469379

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