- Abstract:
-
Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha cells but their activity is low and only ~1% of that in beta cells. Like beta cells, alpha cells respond to hyperglycaemia with K(ATP) channel closure, membrane depolarisation and ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00125-014-3279-8
-
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- Journal:
- Diabetologia
- Volume:
- 57
- Issue:
- 9
- Pages:
- 1749-1761
- Publication date:
- 2014-09-05
- DOI:
- EISSN:
-
1432-0428
- ISSN:
-
0012-186X
- URN:
-
uuid:b833024c-978b-4d23-bb07-23c93f5e1839
- Source identifiers:
-
469379
- Local pid:
- pubs:469379
- Copyright date:
- 2014
Journal article
ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.
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