Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis
Objectives Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating with neighbouring endothelial cells (EC). Surprisingly, little is known about how the development of rheumatoid arthritis (RA) alters these immunomodulatory properties. We examined the effects of phase of RA and disease outcome (resolving vs persistence) on fibroblast crosstalk with EC and regulation of lymphocyte recruitment.
Methods Fibroblasts were isol...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 2.7MB)
- Publisher copy:
- Copyright holder:
- Filer et al
- Copyright date:
- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license.
- CC Attribution (CC BY)