Journal article
Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis
- Abstract:
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Objectives Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating with neighbouring endothelial cells (EC). Surprisingly, little is known about how the development of rheumatoid arthritis (RA) alters these immunomodulatory properties. We examined the effects of phase of RA and disease outcome (resolving vs persistence) on fibroblast crosstalk with EC and regulation of lymphocyte recruitment.
Methods Fibroblasts were isol...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 2.7MB)
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- Publisher copy:
- 10.1136/annrheumdis-2017-211286
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Authors
Funding
British Heart Foundation
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Arthritis Research UK
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European Research Council
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Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Annals of Rheumatic Diseases Journal website
- Volume:
- 76
- Issue:
- 12
- Pages:
- 2105-2112
- Publication date:
- 2017-08-28
- Acceptance date:
- 2017-08-05
- DOI:
- Pubs id:
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pubs:727891
- URN:
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uri:b82f86f4-096c-41f6-9f11-b15eee850b14
- UUID:
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uuid:b82f86f4-096c-41f6-9f11-b15eee850b14
- Local pid:
- pubs:727891
- Paper number:
- 12
Item Description
Terms of use
- Copyright holder:
- Filer et al.
- Copyright date:
- 2017
- Notes:
- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license.
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