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Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis

Abstract:

Objectives Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating with neighbouring endothelial cells (EC). Surprisingly, little is known about how the development of rheumatoid arthritis (RA) alters these immunomodulatory properties. We examined the effects of phase of RA and disease outcome (resolving vs persistence) on fibroblast crosstalk with EC and regulation of lymphocyte recruitment.

Methods Fibroblasts were isol...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/annrheumdis-2017-211286

Authors


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British Heart Foundation More from this funder
Arthritis Research UK More from this funder
European Research Council More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of Rheumatic Diseases Journal website
Volume:
76
Issue:
12
Pages:
2105-2112
Publication date:
2017-08-28
Acceptance date:
2017-08-05
DOI:
Pubs id:
pubs:727891
URN:
uri:b82f86f4-096c-41f6-9f11-b15eee850b14
UUID:
uuid:b82f86f4-096c-41f6-9f11-b15eee850b14
Local pid:
pubs:727891

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