Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis
Objectives Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating with neighbouring endothelial cells (EC). Surprisingly, little is known about how the development of rheumatoid arthritis (RA) alters these immunomodulatory properties. We examined the effects of phase of RA and disease outcome (resolving vs persistence) on fibroblast crosstalk with EC and regulation of lymphocyte recruitment.
Methods Fibroblasts were isol...Expand abstract
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- BMJ Publishing Group Publisher's website
- Annals of Rheumatic Diseases Journal website
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- Filer et al.
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