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Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Abstract:

Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for understanding the nature of immune responses and designing improved vaccines, therapeutics, and diagnostics. In recent years, identification of B-cell epitopes targeted by neutralizing antibodies has facilitated the design of peptide-based vaccines against highly variable pathogens like HIV, respiratory syncytial virus, and Helicobacter pylori; however, none of these products has yet progressed into cli...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1222845110

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
9
Pages:
3304-3309
Publication date:
2013-02-08
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
384332

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