Journal article
The molecular basis of MeCP2 function in the brain
- Abstract:
-
MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome due to its high abundance and the frequency of its target sites. It has been the subject of extensive study because of its link with 'MECP2-related disorders', of which Rett syndrome is the most prevalent. This review integrates evidence from patient mutation data with results of experimental studies using mouse models, cell lines and in vitro systems to critically evaluate our understanding of MeCP2 protein...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Molecular Biology Journal website
- Volume:
- 432
- Issue:
- 6
- Pages:
- 1602-1623
- Publication date:
- 2019-10-17
- Acceptance date:
- 2019-10-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- Pmid:
-
31629770
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1068847
- UUID:
-
uuid:b80c085e-bfd1-423c-bc19-c4ae10238691
- Local pid:
- pubs:1068847
- Source identifiers:
-
1068847
- Deposit date:
- 2019-12-12
Terms of use
- Copyright holder:
- Tillotson and Bird
- Copyright date:
- 2019
- Rights statement:
- © 2019 The Author(s). Published by Elsevier Ltd. This is an open access article published under CC BY 4.0.
- Licence:
- CC Attribution (CC BY)
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