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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.

Abstract:: Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to be a key player in cancer progression. Here, using fluorescent reporters, we shown in cells that, contrary to in vitro analyses, 3-phosphoinositide-dependent protein kinase 1 (PDK1) is complexed to its substrate, PKB. The use of Förster resonance energy transfer detected by both frequency domain and two-photon time domain fluorescence lifetime imaging m...
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APA Style

Calleja, V., Alcor, D., Laguerre, M., Park, J., Vojnovic, B., Hemmings, B., Downward, J., Parker, P., & Larijani, B. (2007). Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biology, 5(4).

MLA Style

Calleja, V., et al. “Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation in Vivo.” PLoS Biology, vol. 5, no. 4, 2007.

Chicago Style

Calleja, V, D Alcor, M Laguerre, J Park, B Vojnovic, B Hemmings, J Downward, P Parker, and B Larijani. 2007. “Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation in Vivo.” PLoS Biology 5 (4).
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Publisher copy:: 10.1371/journal.pbio.0050095

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+ Calleja, V More by this author

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+ Alcor, D More by this author

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+ Laguerre, M More by this author

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+ Park, J More by this author

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+ Vojnovic, B More by this author

Institution:

University of Oxford

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MSD

Department:

Oncology

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Bibliographic Details

Journal:: PLoS biology
Volume:: 5
Issue:: 4
Publication date:: 2007-04-01
DOI:: 10.1371/journal.pbio.0050095
EISSN:: 1545-7885

Item Description

Language:: English
Pubs id:: pubs:132902
UUID:: uuid:b7fea817-433a-42d6-8a5c-ea3094f67753
Local pid:: pubs:132902
Source identifiers:: 132902
Deposit date:: 2013-11-17

Terms of use

Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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