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Journal article

Pathogenic autoantibodies in the lambert-eaton myasthenic syndrome.

Abstract:

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of neuromuscular transmission in which antibodies are directed against voltage-gated calcium channels (VGCCs). We studied the action of LEMS immunoglobulin G (IgG) on cloned human VGCCs stably transfected into human embryonic kidney cells (HEK293). All LEMS IgGs tested bound to the surface of the P/Q-type VGCC cell line and caused a significant reduction in whole-cell calcium currents in these cells. By contrast, only 2 out of...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1254.019

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Annals of the New York Academy of Sciences
Volume:
998
Issue:
1
Pages:
187-195
Publication date:
2003-09-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
Source identifiers:
241637

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