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Evidence that Argos is an antagonistic ligand of the EGF receptor.

Abstract:

Argos, the inhibitor of the Drosophila epidermal growth factor (EGF) receptor, remains the only known extracellular inhibitor of this family of receptors in any organism. The functional domain of Argos includes an atypical EGF domain and it is not clear whether it binds to the EGF receptor or if it acts via a distinct receptor to reduce Egfr activity indirectly. Here we present two lines of evidence that strongly suggest that Argos directly interacts with the EGF receptor. First, Argos is una...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1203702

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Oncogene More from this journal
Volume:
19
Issue:
31
Pages:
3560-3562
Publication date:
2000-07-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232

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