Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions.

Journal article

INTRODUCTION: Activation of the hypoxia response pathway is a feature of many tumours and is one of the key mechanisms associated with tumour growth, chemoresistance and radioresistance. The major component of the hypoxia response pathway is the heterodimeric transcription factor, hypoxia-inducible factor (HIF), which is upregulated in many human cancers. Therefore, HIF is an attractive therapeutic target and several strategies have been developed to target it. AREAS COVERED: Approaches used ...

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Authors: Jones, D; Harris, A

• Publication status: Published
• Journal: Expert opinion on therapeutic targets
• Volume: 16
• Issue: 5
• Pages: 463-480
• Publication date: 2012-05-01
• DOI: 10.1517/14728222.2012.674516
• EISSN: 1744-7631
• ISSN: 1472-8222
• Language: English
• Keywords: Humans; Up-Regulation; Animals; Neoplasms; Basic Helix-Loop-Helix Transcription Factors; Gene Expression Regulation, Neoplastic; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Targeted Therapy; Anoxia; Drug Design; Antineoplastic Agents