Journal article
Non-adherence in non-inferiority trials: pitfalls and recommendations
- Abstract:
- Non-adherence in non-inferiority trials can affect treatment effect estimates and often increases the chance of claiming non-inferiority under the standard intention-to-treat analysis. This article discusses the implications of different patterns of non-adherence in non-inferiority trials and offers practical recommendations for trial design, alternative analysis strategies, and outcome reporting to reduce bias in treatment estimates and improve transparency in reporting.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, 711.2KB, Terms of use)
-
- Publisher copy:
- 10.1136/bmj.m2215
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- BMJ More from this journal
- Volume:
- 370
- Article number:
- m2215
- Publication date:
- 2020-07-01
- Acceptance date:
- 2020-05-07
- DOI:
- EISSN:
-
1756-1833
- ISSN:
-
0959-8138
- Pmid:
-
32611541
- Language:
-
English
- Keywords:
- Pubs id:
-
1116730
- Local pid:
-
pubs:1116730
- Deposit date:
-
2020-08-13
Terms of use
- Copyright holder:
- Mo et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record