Spironolactone is an effective and well tolerated systemic antiandrogen therapy for Hirsute women.

Journal article

We treated 22 hirsute women with spironolactone in an open trial to determine whether it caused objective changes in hair growth. Among them, 18 women completed 12 months therapy with 200 mg spironolactone daily. During this period, the mean daily linear growth rates of hair on the face, abdomen, and thigh were reduced to 66% (P less than 0.001), 75% (P less than 0.01), and 72% (P less than 0.001) of their pretreatment values. The mean hair shaft diameters were reduced to 83% (P less than 0.0...

Expand abstract

Authors: Barth, J; Cherry, C; Wojnarowska, F; Dawber, R

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 68
• Issue: 5
• Pages: 966-970
• Publication date: 1989-05-01
• DOI: 10.1210/jcem-68-5-966
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Menstrual Cycle; Hair; Female; Hirsutism; Adult; Drug Tolerance; Androgen Antagonists; Spironolactone; Humans