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Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk

Abstract:

Background: Differences between gastrointestinal and cardiovascular effects of traditional NSAID or cyclooxygenase-2 selective inhibitor (coxib) are affected by drug, dose, duration, outcome definition, and patient gastrointestinal and cardiovascular risk factors. We calculated the absolute risk for each effect. Methods: We sought studies with large amounts of information to calculate annualised rates for clearly defined gastrointestinal (complicated upper gastrointestinal perforations, ulcer...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/1471-2474-8-73

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Pain Research
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Pain Research
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Pain Research
Role:
Author
Pfizer Ltd. More from this funder
Oxford Pain Research Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Musculoskeletal Disorders Journal website
Volume:
8
Publication date:
2007-08-01
DOI:
ISSN:
1471-2474
Language:
English
Keywords:
Subjects:
UUID:
uuid:b7d3f389-124a-4183-925f-f91228067a03
Local pid:
ora:1803
Deposit date:
2008-03-20

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