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Journal article

Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.

Abstract:

Hypertension is associated with heightened cardiac sympathetic drive whilst statins reduce angiotensin II (ATII) signalling, superoxide anion production and increase nitric oxide bioavailability, events that can potentially reduce peripheral cardiac sympathetic neurotransmission. We therefore investigated whether pravastatin alters peripheral cardiac sympathetic control in the spontaneously hypertensive rat (SHR). SHRs (16-18 weeks) had significantly (p<0.05) enhanced atrial (3)H-norepinep...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2010.09.025

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Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
Journal:
Journal of molecular and cellular cardiology
Volume:
50
Issue:
1
Pages:
99-106
Publication date:
2011-01-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:b7d27d65-8999-4c65-b97f-f1d09639847e
Source identifiers:
106125
Local pid:
pubs:106125

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