- Abstract:
-
Hypertension is associated with heightened cardiac sympathetic drive whilst statins reduce angiotensin II (ATII) signalling, superoxide anion production and increase nitric oxide bioavailability, events that can potentially reduce peripheral cardiac sympathetic neurotransmission. We therefore investigated whether pravastatin alters peripheral cardiac sympathetic control in the spontaneously hypertensive rat (SHR). SHRs (16-18 weeks) had significantly (p<0.05) enhanced atrial (3)H-norepinep...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.yjmcc.2010.09.025
-
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- Journal:
- Journal of molecular and cellular cardiology
- Volume:
- 50
- Issue:
- 1
- Pages:
- 99-106
- Publication date:
- 2011-01-05
- DOI:
- EISSN:
-
1095-8584
- ISSN:
-
0022-2828
- URN:
-
uuid:b7d27d65-8999-4c65-b97f-f1d09639847e
- Source identifiers:
-
106125
- Local pid:
- pubs:106125
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.
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