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Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.

Abstract:

Platelets play an important role in hemostasis, with inappropriate platelet activation being a major contributor to debilitating and often fatal thrombosis by causing myocardial infarction and stroke. Although current antithrombotic treatment is generally well tolerated and effective, many patients still experience cardiovascular problems, which may reflect the existence of alternative underlying regulatory mechanisms in platelets to those targeted by existing drugs. In this study, we define ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
Blood More from this journal
Volume:
111
Issue:
2
Pages:
605-612
Publication date:
2008-01-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:244378
UUID:
uuid:b7c53bfa-1d8e-4961-b688-67ffdf865382
Local pid:
pubs:244378
Source identifiers:
244378
Deposit date:
2012-12-19

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