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Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.

Abstract:

The putative Major Facilitator Superfamily (MFS) transporter, SV2A, is the target for levetiracetam (LEV), which is a successful anti-epileptic drug. Furthermore, SV2A knock out mice display a severe seizure phenotype and die after a few weeks. Despite this, the mode of action of LEV is not known at the molecular level. It would be extremely desirable to understand this more fully in order to aid the design of improved anti-epileptic compounds. Since there is no structure for SV2A, homology m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0116589

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
10
Issue:
2
Pages:
e0116589
Publication date:
2015-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
508050
Language:
English
Keywords:
Pubs id:
pubs:508050
UUID:
uuid:b7b4a1f1-0ade-4d77-8374-6c5389b21bcf
Local pid:
pubs:508050
Deposit date:
2015-06-30

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