Journal article
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.
- Abstract:
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The putative Major Facilitator Superfamily (MFS) transporter, SV2A, is the target for levetiracetam (LEV), which is a successful anti-epileptic drug. Furthermore, SV2A knock out mice display a severe seizure phenotype and die after a few weeks. Despite this, the mode of action of LEV is not known at the molecular level. It would be extremely desirable to understand this more fully in order to aid the design of improved anti-epileptic compounds. Since there is no structure for SV2A, homology m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.6MB)
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- Publisher copy:
- 10.1371/journal.pone.0116589
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Lee, J
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 10
- Issue:
- 2
- Pages:
- e0116589
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
508050
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:508050
- UUID:
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uuid:b7b4a1f1-0ade-4d77-8374-6c5389b21bcf
- Local pid:
- pubs:508050
- Deposit date:
- 2015-06-30
Terms of use
- Copyright holder:
- Lee et al
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 Lee et al. This is an open access
article distributed under the terms of the Creative
Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited.
- Licence:
- CC Attribution (CC BY)
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