Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard

Journal article

Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens. © 1983.

Authors: Sanderson, A; Beverley, P

• Journal: Immunology Today
• Volume: 4
• Issue: 8
• Pages: 211-213
• Publication date: 1983-01-01
• DOI: 10.1016/0167-5699(83)90027-0
• ISSN: 0167-5699
• Language: English