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The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.

Abstract:

In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways for the activation of p38 but spontaneously engaged the metabolic master regulator AMPK to trigger recruitment of p38 to the scaffold protein TAB1, which caused autophosphorylati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.2981

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
15
Issue:
10
Pages:
965-972
Publication date:
2014-08-24
Acceptance date:
2014-07-29
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
616425

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