Journal article
The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.
- Abstract:
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In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways for the activation of p38 but spontaneously engaged the metabolic master regulator AMPK to trigger recruitment of p38 to the scaffold protein TAB1, which caused autophosphorylati...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.7MB)
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- Publisher copy:
- 10.1038/ni.2981
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Authors
Funding
+ Biotechnology and Biological Science Research Council
More from this funder
Funding agency for:
Henson, S
Grant:
BB/J006750/1
+ Biotechnology and Biological Science Research Council
More from this funder
Funding agency for:
Akbar, A
Grant:
BB/J006750/1
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 15
- Issue:
- 10
- Pages:
- 965-972
- Publication date:
- 2014-08-24
- Acceptance date:
- 2014-07-29
- DOI:
- EISSN:
-
1529-2916
- ISSN:
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1529-2908
- Source identifiers:
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616425
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:616425
- UUID:
-
uuid:b7b0a355-f100-45ef-a3e0-45dd72eb4bbe
- Local pid:
- pubs:616425
- Deposit date:
- 2016-05-11
Terms of use
- Copyright holder:
- Lanna et al
- Copyright date:
- 2014
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group under license. This is the accepted manuscript version of the article. The final version is available online from Nature at: [10.1038/ni.2981].
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