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Exploring the mechanisms of macrolides in cystic fibrosis.

Abstract:

Several studies have reported clinical improvements in cystic fibrosis (CF) patients on macrolide antibiotics although the mechanism of action remains unclear. We conducted an open-label study of azithromycin (500 mg daily for 2 weeks) in 9 adult CF patients to explore 3 possible mechanisms: up-regulation of the multi-drug resistance (MDR) or cystic fibrosis transmembrane regulator (CFTR) proteins, correction of epithelial ion transport and reduced bacterial adherence. End-points included nas...

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Publication status:
Published

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Publisher copy:
10.1016/j.rmed.2005.07.016

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
Journal:
Respiratory medicine More from this journal
Volume:
100
Issue:
4
Pages:
687-697
Publication date:
2006-04-01
DOI:
EISSN:
1532-3064
ISSN:
0954-6111
Language:
English
Keywords:
Pubs id:
pubs:246458
UUID:
uuid:b7a6b202-b5a5-49aa-a79d-1c1b846769bd
Local pid:
pubs:246458
Source identifiers:
246458
Deposit date:
2012-12-19

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