Exploring the mechanisms of macrolides in cystic fibrosis.

Journal article

Several studies have reported clinical improvements in cystic fibrosis (CF) patients on macrolide antibiotics although the mechanism of action remains unclear. We conducted an open-label study of azithromycin (500 mg daily for 2 weeks) in 9 adult CF patients to explore 3 possible mechanisms: up-regulation of the multi-drug resistance (MDR) or cystic fibrosis transmembrane regulator (CFTR) proteins, correction of epithelial ion transport and reduced bacterial adherence. End-points included nas...

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Authors: Equi, A; Davies, J; Painter, H; Hyde, S; Bush, A

• Publication status: Published
• Journal: Respiratory medicine
• Volume: 100
• Issue: 4
• Pages: 687-697
• Publication date: 2006-04-01
• DOI: 10.1016/j.rmed.2005.07.016
• EISSN: 1532-3064
• ISSN: 0954-6111
• Language: English
• Keywords: Nasal Mucosa; Adult; P-Glycoprotein; Anti-Bacterial Agents; Forced Expiratory Volume; Male; Ion Transport; Azithromycin; Humans; Female; Cystic Fibrosis; Vital Capacity; Pseudomonas aeruginosa; RNA, Messenger; Cell Adhesion; Cystic Fibrosis Transmembrane Conductance Regulator; Up-Regulation