- Abstract:
-
The safety and immunogenicity of plasmid pTHr DNA, modified vaccinia virus Ankara (MVA) human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four Phase I clinical trials in Kenya and Uganda. Both vaccines, expressing HIV-1 subtype A gag p24/p17 and a string of CD8 T-cell epitopes (HIVA), were generally safe and well-tolerated. At the dosage levels and intervals tested, the percentage of vaccine recipients with HIV-1-specific cell-mediated immune responses, assessed...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.vaccine.2008.02.071
-
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- Volume:
- 26
- Issue:
- 22
- Pages:
- 2788-2795
- Publication date:
- 2008-05-05
- DOI:
- EISSN:
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1873-2518
- ISSN:
-
0264-410X
- URN:
-
uuid:b7a4101b-d59c-4f2b-8956-bbcb57d3a8b5
- Source identifiers:
-
67014
- Local pid:
- pubs:67014
- Copyright date:
- 2008
Conference
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa.
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