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Journal article

Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.

Abstract:

Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collagenase resistance may play an important physiological role. To understand the mechanism of this resistance, we studied interactions of alpha1(I)(3) homotrimers and normal alpha1(I)(2)alpha2(I) heterotrimers with fibroblast collagenase (MMP-1). Similar MMP-1 binding to the two isoforms and simila...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.102079

Authors


Makareeva, E More by this author
Kuznetsova, NV More by this author
DeRidder, AM More by this author
Sutter, MB More by this author
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Journal:
The Journal of biological chemistry
Volume:
285
Issue:
29
Pages:
22276-22281
Publication date:
2010-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:b789f0b6-450c-4ca2-8164-1915a17399cf
Source identifiers:
227433
Local pid:
pubs:227433

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