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DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact

Abstract:

The atypical protein tyrosine phosphatase enzyme, dual-specificity phosphate 15 (DUSP15) is thought to be activated by myelin regulatory factor (MyRF) and to have a role in oligodendrocyte differentiation. Here, we assess whether Dusp15 is reduced in the hippocampus of mice with conditional knock-out of Myrf in oligodendrocyte precursor cells. Using quantitative polymerase chain reaction (qPCR) we found that Dusp15 expression was indeed lower in these mice. Alterations in myelin have been ass...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0281264

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Role:
Author
ORCID:
0000-0003-0449-0484
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Name:
Wellcome Trust
Grant:
110027/Z/15/Z
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
18
Issue:
2
Article number:
e0281264
Publication date:
2023-02-02
Acceptance date:
2023-01-18
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
1326580
Local pid:
pubs:1326580
Deposit date:
2023-02-03

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