Aplysia californica mediated cyclisation of novel 3'-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose.

Journal article

Cyclic ADP-ribose mobilizes intracellular Ca2+ in a variety of cells. To elucidate the nature of the interaction between the C3' substituent of cADP-ribose and the cADPR receptor, three analogues of NAD+ modified in the adenosine ribase (xyloNAD+ 3'F-xyloNAD+ and 3'F-NAD+ were chemically synthesised from D-xylose and adenine starting materials. 3'F-NAD+ was readily converted to cyclic 3'F-ADP ribose by the action of the cyclase enzyme derived from the mollusc Aplysia californica. XyloNAD+ and...

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Authors: Mort, C; Migaud, M; Galione, A; Potter, B

• Publication status: Published
• Journal: Bioorganic and medicinal chemistry
• Volume: 12
• Issue: 2
• Pages: 475-487
• Publication date: 2004-01-01
• DOI: 10.1016/j.bmc.2003.10.012
• EISSN: 1464-3391
• ISSN: 0968-0896
• Language: English
• Keywords: ADP-ribosyl Cyclase; Cyclic ADP-Ribose; Ovum; Sea Urchins; Calcium; NAD; Animals; Cyclization; Aplysia; Biochemistry; Hydrogen Bonding; Kinetics