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Journal article

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.

Abstract:

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a small conductance chloride ion channel that may interact directly with other channels including the epithelial sodium channel (ENaC). CFTR is known to be more abundant in the airway epithelium during the second trimester of human development than after birth. This could be a consequence of the change in function of the respiratory epithelium from chloride secretion to sodium absorption near term. Alternatively it migh...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/11.2.125

Authors


Broackes-Carter, FC More by this author
Mouchel, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Bassett, J More by this author
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Journal:
Human molecular genetics
Volume:
11
Issue:
2
Pages:
125-131
Publication date:
2002-01-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:b750c4f6-b58f-43ba-be1d-5f4c8e389511
Source identifiers:
124693
Local pid:
pubs:124693

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